Parthenolide suppresses pancreatic cell growth by autophagy-mediated apoptosis
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چکیده
منابع مشابه
Parthenolide suppresses pancreatic cell growth by autophagy-mediated apoptosis
Pancreatic cancer is an aggressive malignancy and is unresponsive to conventional chemotherapies. Parthenolide, a sesquiterpene lactone isolated from feverfew, has exhibited potent anticancer effects against various cancers. The purpose of this report was to investigate the effect and underlying mechanism of parthenolide in human pancreatic cancer Panc-1 and BxPC3 cells. The results demonstrate...
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Parthenolide (PT), a principal active component in medicinal plants, has been used conventionally to treat migraine and inflammation. This component has recently been reported to induce apoptosis in cancer cells, through mitochondrial dysfunction. In the present study, we investigated PT-mediated cell death signaling pathway by focusing on the involvement of Bcl-2 family members in human colore...
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ژورنال
عنوان ژورنال: OncoTargets and Therapy
سال: 2017
ISSN: 1178-6930
DOI: 10.2147/ott.s117250